Chloroquine Diphosphate


CAS No. : 50-63-5

Chloroquine Diphosphate,50-63-5
Product Details
Cat No:A000578
Synonyms:NA
Molecular Formula:C₁₈H₂₆ClN₃·2H₃PO₄
Molecular Weight:515.86
Target:Autophagy
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Form:Powder
Appearance:White or almost white crystalline powder
Source:Semi-synthetic
pH:3.8-4.3
Assay:98.5-101.0% (on dried basis)
Loss on Drying:≤2.0%
Heavy Metals:≤20ppm
Cat No:A000578
Cas No:50-63-5
Product-Name:Chloroquine Diphosphate
MDL No:MFCD00069852
InChI:InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChIKey:QKICWELGRMTQCR-UHFFFAOYSA-N
SMILES:CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
Chloroquine phosphate is an antimalarial 4-aminoquinoline compound used to inhibit growth of malarial parasites and treat malarial infections.
Chloroquine enters a malarial parasite and binds to hemozoin, a non-toxic polymer formed from the parasite in an infected red blood cell. The chloroquine:hemozin complex interferes with normal membrane function leading to build-up of chloroquine:hemozin complexes and ultimately, cell lysis.
Sullivan, David J. et. al. /On the Molecular Mechanism of Chloroquine/'s Antimalarial Action./ PNAS 93 (1996): 11865-1870. Nih.gov. Web. 2 Oct. 2013.

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