CAS No. : 67392-87-4

Product Details
Cat No:A000572
Synonyms:67392-87-4; Dihydrospirorenone; Drospirenona; Drospirenonum; Dehydrospirorenone
Molecular Formula:C24H30O3
Molecular Weight:366.49
Target:Estrogen/progestogen Receptor
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Appearance:Solid powder
Purity: > 98%
Cat No:A000572
Cas No:67392-87-4
Drospirenone is a synthetic progestogen exhibiting antiandrogenic and antimineralocorticoid activity. This drug is used in oral contraceptives. Drospirenone binds to the progesterone receptor, the resulting complex becomes activated and binds to specific sites on DNA. This results in a suppression of LH activity and an inhibition of ovulation as well as an alteration in the cervical mucus and endometrium. This leads to an increased difficulty of sperm entry into the uterus and implantation.
1: Harada T, Kosaka S, Elliesen J, Yasuda M, Ito M, Momoeda M. Ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen for the management of endometriosis-associated pelvic pain: a randomized controlled trial. Fertil Steril. 2017 Nov;108(5):798-805. doi: 10.1016/j.fertnstert.2017.07.1165. Epub 2017 Sep 11. PubMed PMID: 28911925.
2: Baydoun E, Atia-Tul-Wahab, Iqbal S, Smith C, Choudhary MI. Biotransformation of drospirenone, a contraceptive drug, with Cunninghamella elegans. Steroids. 2017 Oct;126:30-34. doi: 10.1016/j.steroids.2017.07.010. Epub 2017 Jul 30. PubMed PMID: 28768150.
3: Apter D, Zimmerman Y, Beekman L, Mawet M, Maillard C, Foidart JM, Coelingh Bennink HJT. Estetrol combined with drospirenone: an oral contraceptive with high acceptability, user satisfaction, well-being and favourable body weight control. Eur J Contracept Reprod Health Care. 2017 Aug;22(4):260-267. doi: 10.1080/13625187.2017.1336532. Epub 2017 Jun 22. PubMed PMID: 28641030.
4: Cappello T, Fernandes D, Maisano M, Casano A, Bonastre M, Bebianno MJ, Mauceri A, Fasulo S, Porte C. Sex steroids and metabolic responses in mussels Mytilus galloprovincialis exposed to drospirenone. Ecotoxicol Environ Saf. 2017 Sep;143:166-172. doi: 10.1016/j.ecoenv.2017.05.031. Epub 2017 May 23. PubMed PMID: 28544938.
5: Momoeda M, Kondo M, Elliesen J, Yasuda M, Yamamoto S, Harada T. Efficacy and safety of a flexible extended regimen of ethinylestradiol/drospirenone for the treatment of dysmenorrhea: a multicenter, randomized, open-label, active-controlled study. Int J Womens Health. 2017 May 2;9:295-305. doi: 10.2147/IJWH.S134576. eCollection 2017. PubMed PMID: 28496369; PubMed Central PMCID: PMC5422539.
6: Larivée N, Suissa S, Coulombe J, Tagalakis V, Filion KB. Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: An Assessment of Risk in First-Time Users and Restarters. Drug Saf. 2017 Jul;40(7):583-596. doi: 10.1007/s40264-017-0525-2. PubMed PMID: 28382493.
7: Park BR, Park HN, Jung JB, Lee ES, Kim JS, Choi GY, Lee JJ, Lee IS. Efficacy and safety of drospirenone 2 mg/17β-estradiol 1 mg hormone therapy in Korean postmenopausal women. Obstet Gynecol Sci. 2017 Mar;60(2):213-217. doi: 10.5468/ogs.2017.60.2.213. Epub 2017 Mar 16. PubMed PMID: 28344964; PubMed Central PMCID: PMC5364105.
8: Larivée N, Suissa S, Khosrow-Khavar F, Tagalakis V, Filion KB. Drospirenone-containing oral contraceptive pills and the risk of venous thromboembolism: a systematic review of observational studies. BJOG. 2017 Sep;124(10):1490-1499. doi: 10.1111/1471-0528.14623. Epub 2017 May 5. Review. PubMed PMID: 28276140.
9: Makabe T, Koga K, Miyashita M, Takeuchi A, Sue F, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y. Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells. J Reprod Immunol. 2017 Feb;119:44-48. doi: 10.1016/j.jri.2016.12.002. Epub 2016 Dec 29. PubMed PMID: 28064076.
10: Mansour D, Westhoff C, Kher U, Korver T. Pooled analysis of two randomized, open-label studies comparing the effects of nomegestrol acetate/17β-estradiol and drospirenone/ethinyl estradiol on bleeding patterns in healthy women. Contraception. 2017 Apr;95(4):390-397. doi: 10.1016/j.contraception.2016.12.001. Epub 2016 Dec 20. PubMed PMID: 28011288.
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