Palonosetron HCl


CAS No. : 135729-62-3

Palonosetron HCl,135729-62-3
Product Details
Cat No:A000372
Synonyms:RS 25259, RS 25259 197
Molecular Formula:C19H24N2O • HCl
Molecular Weight:332.9
Target:5-HT Receptor
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Appearance:Crystalline solid
Purity:98%
Cat No:A000372
Cas No:135729-62-3
Product-Name:Palonosetron HCl
Related Cas:135729-61-2 (free base)
IUPAC Name:(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one;hydrochloride
InChI:InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1
InChIKey:OLDRWYVIKMSFFB-SSPJITILSA-N
SMILES:C1CC2CN(C(=O)C3=C2C(=CC=C3)C1)C4CN5CCC4CC5.Cl
Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Palonosetron is a highly potent, selective, second-generation 5-HT3 receptor antagonist with a 5-HT3 receptor binding affinity that is ∼100-fold higher than other 5-HT3 receptor antagonists (pKi 10.5 compared with 8.91 for granisetron, 8.81 for tropisetron, 8.39 for ondansetron, 7.6 for dolasetron). Palonosetron also has an extended plasma elimination half-life of ∼40 h, significantly longer than others in its class (ondansetron, 4 h; tropisetron, 7.3 h; dolasetron, 7.5 h; ranisetron, 8.9 h).
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