CAS No. : 84371-65-3

Product Details
Cat No:A000368
Synonyms:84371-65-3; Mifeprex; Mifegyne; RU-486; Corlux
Molecular Formula:C₂₉H₃₅NO₂
Molecular Weight:429.59
Target:Glucocorticoid Receptor
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Appearance:Solid powder
Purity: > 98%
Cat No:A000368
Cas No:84371-65-3
MDL No:MFCD00867226
Mifepristone is a synthetic steroid compound used as a pharmaceutical. It is used as an abortifacient in the first two months of pregnancy, and in smaller doses as an emergency contraceptive. During early trials, it was known as RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed—often amid controversy. It is marketed under tradenames Mifegyne and Mifeprex.
1: Li HR, Li YX, Li TT, Fan H, Ng EH, Yeung WS, Ho PC, Lee KF. Effect of ulipristal acetate and mifepristone at emergency contraception dose on the embryo-endometrial attachment using an in vitro human trophoblastic spheroid and endometrial cell co-culture model. Hum Reprod. 2017 Nov 7:1-9. doi: 10.1093/humrep/dex328. [Epub ahead of print] PubMed PMID: 29121217.
2: Davenport M, Delgado G, Harrison MP, Khauv V. Embryo Survival after Mifepristone: A Systematic Review of the Literature. Issues Law Med. 2017 Spring;32(1):3-18. PubMed PMID: 29108160.
3: Loi M, Sarabdjitsingh RA, Tsouli A, Trinh S, Arp M, Krugers HJ, Karst H, van den Bos R, Joëls M. Transient Prepubertal Mifepristone Treatment Normalizes Deficits in Contextual Memory and Neuronal Activity of Adult Male Rats Exposed to Maternal Deprivation. eNeuro. 2017 Nov 2;4(5). pii: ENEURO.0253-17.2017. doi: 10.1523/ENEURO.0253-17.2017. eCollection 2017 Sep-Oct. PubMed PMID: 29098176; PubMed Central PMCID: PMC5666324.
4: Liu L, Zhou F, Qin J, Qian Z, Huang L. Roles of Mifepristone on the Regulation of Cytotoxic Lymphocytes and Regulatory T Cells. Gynecol Obstet Invest. 2017 Oct 28. doi: 10.1159/000455848. [Epub ahead of print] PubMed PMID: 29080885.
5: Yang Y, Li X, Mamouni K, Kucuk O, Wu D. Mifepristone Has Limited Activity to Enhance the In Vivo Efficacy of Docetaxel and Enzalutamide Against Bone Metastatic and Castration-Resistant Prostate Cancer. Anticancer Res. 2017 Nov;37(11):6235-6243. PubMed PMID: 29061806.
6: Alam A, Lotarevich T, Das TR, Reichenbach L, Bracken H. Mifepristone-misoprostol for menstrual regulation in public sector facilities in Bangladesh. Int J Gynaecol Obstet. 2017 Oct 19. doi: 10.1002/ijgo.12356. [Epub ahead of print] PubMed PMID: 29049861.
7: Murtagh C, Wells E, Raymond EG, Coeytaux F, Winikoff B. Exploring the Feasibility of Obtaining Mifepristone and Misoprostol from the Internet. Contraception. 2017 Oct 10. pii: S0010-7824(17)30475-4. doi: 10.1016/j.contraception.2017.09.016. [Epub ahead of print] PubMed PMID: 29030227.
8: Nguyen D, Mizne S. Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men. Adv Ther. 2017 Oct;34(10):2371-2385. doi: 10.1007/s12325-017-0621-9. Epub 2017 Oct 11. PubMed PMID: 29022184; PubMed Central PMCID: PMC5656713.
9: Bernal-Sore I, Navarro-Marquez M, Osorio-Fuentealba C, Díaz-Castro F, Del Campo A, Donoso-Barraza C, Porras O, Lavandero S, Troncoso R. Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells. Mol Cell Endocrinol. 2017 Sep 21. pii: S0303-7207(17)30513-0. doi: 10.1016/j.mce.2017.09.028. [Epub ahead of print] PubMed PMID: 28943275.
10: Aiken ARA, Guthrie KA, Schellekens M, Trussell J, Gomperts R. Barriers to accessing abortion services and perspectives on using mifepristone and misoprostol at home in Great Britain. Contraception. 2017 Sep 20. pii: S0010-7824(17)30435-3. doi: 10.1016/j.contraception.2017.09.003. [Epub ahead of print] PubMed PMID: 28941978.
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