Estriol


CAS No. : 50-27-1

Estriol,50-27-1
Product Details
Cat No:A000212
Synonyms:Oestriol; 50-27-1; Estratriol; Ovestin; Ovestrion
Molecular Formula:C18H24O3
Molecular Weight:288.4
Target:Estrogen/progestogen Receptor
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Appearance:Solid powder
Purity: > 98%
Cat No:A000212
Cas No:50-27-1
Product-Name:Estriol
InChI:1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
InChIKey:PROQIPRRNZUXQM-ZXXIGWHRSA-N
SMILES:CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O
Estriol (also oestriol) is one of the three main estrogens produced by the human body. In pregnant women with multiple sclerosis (MS), estriol reduces the disease/'s symptoms noticeably, according to researchers at UCLA/'s Geffen Medical School. Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol. Estriol may play a role in the development of breast cancer, but based on in vitro research does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. (Source: http://en.wikipedia.org/wiki/Estriol).
1: Wang C, Guan D, Chen C, He S, Liu X, Wang C, Wu H. Rapid detection of unconjugated estriol in the serum via superparamagnetic lateral flow immunochromatographic assay. Anal Bioanal Chem. 2017 Nov 2. doi: 10.1007/s00216-017-0699-6. [Epub ahead of print] PubMed PMID: 29098334.
2: Mendes-Bastos P. Plantar keratoderma climatericum: Successful improvement with a topical estriol cream. J Cosmet Dermatol. 2017 Sep 19. doi: 10.1111/jocd.12422. [Epub ahead of print] PubMed PMID: 28929614.
3: Otsuka M, Kadokawa H. GPR30 mediates estrone, estriol, and estradiol to suppress gonadotropin-releasing hormone-induced luteinizing hormone secretion in the anterior pituitary of heifers. J Reprod Dev. 2017 Oct 18;63(5):519-525. doi: 10.1262/jrd.2017-035. Epub 2017 Aug 6. PubMed PMID: 28781349; PubMed Central PMCID: PMC5649102.
4: Cruz VL, Steiner ML, Pompei LM, Strufaldi R, Fonseca FLA, Santiago LHS, Wajsfeld T, Fernandes CE. Randomized, double-blind, placebo-controlled clinical trial for evaluating the efficacy of fractional CO2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women. Menopause. 2017 Jul 31. doi: 10.1097/GME.0000000000000955. [Epub ahead of print] PubMed PMID: 28763401.
5: Raymundo-Pereira PA, Campos AM, Vicentini FC, Janegitz BC, Mendonça CD, Furini LN, Boas NV, Calegaro ML, Constantino CJL, Machado SAS, Oliveira ON Jr. Sensitive detection of estriol hormone in creek water using a sensor platform based on carbon black and silver nanoparticles. Talanta. 2017 Nov 1;174:652-659. doi: 10.1016/j.talanta.2017.06.058. Epub 2017 Jun 27. PubMed PMID: 28738637.
6: Liu J, Li S, Li X, Gao Y, Ling W. Removal of estrone, 17β-estradiol, and estriol from sewage and cow dung by immobilized Novosphingobium sp. ARI-1. Environ Technol. 2017 Jul 27:1-11. doi: 10.1080/09593330.2017.1355935. [Epub ahead of print] PubMed PMID: 28707514.
7: Ramírez-Sánchez IM, Tuberty S, Hambourger M, Bandala ER. Resource efficiency analysis for photocatalytic degradation and mineralization of estriol using TiO(2) nanoparticles. Chemosphere. 2017 Oct;184:1270-1285. doi: 10.1016/j.chemosphere.2017.06.046. Epub 2017 Jun 14. PubMed PMID: 28672726.
8: Rueda C, Osorio AM, Avellaneda AC, Pinzón CE, Restrepo OI. The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review. Climacteric. 2017 Aug;20(4):321-330. doi: 10.1080/13697137.2017.1329291. Epub 2017 Jun 16. PubMed PMID: 28622049.
9: Ali ES, Mangold C, Peiris AN. Estriol: emerging clinical benefits. Menopause. 2017 Sep;24(9):1081-1085. doi: 10.1097/GME.0000000000000855. PubMed PMID: 28375935.
10: Caruso S, Cianci S, Vitale SG, Matarazzo MG, Amore FF, Cianci A. Effects of ultralow topical estriol dose on vaginal health and quality of life in postmenopausal women who underwent surgical treatment for pelvic organ prolapse. Menopause. 2017 Aug;24(8):900-907. doi: 10.1097/GME.0000000000000851. PubMed PMID: 28350758.
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