3'-Azido-3'-deoxy-5-methylcytidine

• CAT Number: I019492
• CAS Number: 1282040-14-5
• Molecular Formula: C₁₀H₁₄N₆O₄
• Molecular Weight: 282.26
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-amino-1-[(2R,3R,4S,5S)-4-azido-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
• InChI: InChI=1S/C10H14N6O4/c1-4-2-16(10(19)13-8(4)11)9-7(18)6(14-15-12)5(3-17)20-9/h2,5-7,9,17-18H,3H2,1H3,(H2,11,13,19)/t5-,6-,7-,9-/m1/s1
• InChIKey: HQIDXEHGLJUNPT-JXOAFFINSA-N
• SMILES: CC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)N=[N+]=[N-])O

3′-Azido-3′-deoxy-5-methylcytidine (Cat No.:I019492) is a potent inhibitor of xenotropic murine leukemia-related retrovirus (XMRV) in MCF-7 cells, with a CC50 value of 43.5 μM. It also exhibits inhibitory activity against HIV-1 reverse transcriptase in peripheral blood mononuclear cells (PBM), with an EC50 value of 0.06 μM. These properties suggest its potential as an antiviral agent against both XMRV and HIV-1.

Reference

[1]. Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948.