17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α - CAS 1027401-98-4

A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F derivatives have been approved for the treatment of glaucoma. These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. 17-trifluoromethylphenyl-13,14-dihydro trinor PGF (17-TFM-PGF) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding. As an ocular hypotensive agent, it is expected that 17-TFM-PGF would act very much like the free acid of latanoprost.

Catalog Number: R065116

CAS Number: 1027401-98-4

PubChem Substance ID:355076938

Molecular Formula: C24H35F3O5

Molecular Weight:460.534

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms17-TFM-PGF1α

Property

Molecular Formula: C24H35F3O5
Molecular Weight460.534
Purity≥95%
Storage-20°C

Computed Descriptor

IUPAC Name7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pentyl]cyclopentyl]heptanoic acid
InChIInChI=1S/C24H35F3O5/c25-24(26,27)17-7-5-6-16(14-17)10-11-18(28)12-13-20-19(21(29)15-22(20)30)8-3-1-2-4-9-23(31)32/h5-7,14,18-22,28-30H,1-4,8-13,15H2,(H,31,32)/t18-,19+,20+,21-,22+/m0/s1
InChIKeyDSVAWVBHUBDAPY-AHJNKEMKSA-N
SMILESC1C(C(C(C1O)CCC(CCC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O)O