α-conotoxin-PeIA
α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 µM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 µM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.
Catalog Number: P000392
Molecular Formula: C65H98N22O21S4
Molecular Weight:1651.9 Da
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Property
Molecular Formula: | C65H98N22O21S4 |
---|---|
Molecular Weight | 1651.9 Da |
Target: | Discriminates between α9α10 and α7 nAChRs |
Purity | ≥95% |
Storage | RT |