(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the synthesis of prostaglandin E2 (PGE2) induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells. (±)-γ-Tocopherol inhibits LPS-induced nitrite release and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells and reduces COX-2 activity in A549 cells pretreated with IL-1β. Serum levels of (±)-γ-tocopherol are decreased in patients with cardiovascular disease.
(±)-γ-Tocopherol, 7,8-Dimethyltocol, all-rac-γ-Tocopherol, DL-γ-Tocopherol
|Storage:||Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Appearance:||A solution in hexane|
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For research use only. Not Intended for Therapeutic Use!
1. Jiang, Q., Christen, S., Shigenaga, M.K., et al. γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. American Journal of Clinical Nutrition 74, 714-722 (2001). 2. Cooney, R.V., Franke, A.A., Harwood, P.J., et al. γ-Tocopherol detoxification of nitrogen dioxide: Superiority to α-tocopherol. Proceedings of the National Academy of Sciences of the United States of America 90, 1771-1775 (1993). 3. Jiang, Q., Elson-Schwab, I., Courtemanche, C., et al. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 97, 11494-11499 (2000).