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Scriptaid CAS: 287383-59-9

Category: Inhibitors
Product Name: Scriptaid
Cat No: I002985
CAS No: 287383-59-9
Synonyms: 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
Molecular Formula: C18H18N2O4
Molecular Weight: 326.4
SMILES: O=C(C1=CC=CC2=C1C3=CC=C2)N(CCCCCC(NO)=O)C3=O
InChI: InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChIKey: JTDYUFSDZATMKU-UHFFFAOYSA-N
Solubility: 10 mM in DMSO
Target: HDAC
Storage: powder
CAS 287383-59-9,Scriptaid
  • Description

Scriptaid(Scriptide; GCK-1026) is an inhibitor of HDAC; shows a greater effect on acetylated H4 than H3.
IC50 Value:
Target: HDAC
in vitro: Scriptaid induces high rates of somatic cell nuclear transfer (SCNT) oocytes development to the blastocyst stage and allowed full-term development (3.4, 4.2, 7.6, 6.8, and 4.1%) with all concentrations (50, 100, 250, 500, and 2000 nM respectively). Scriptaid improves the full-term development of cloned B6D2F1embryos in a dose-dependent manner with the maximum effect at 250 nM. Scriptaid enables the clone of all the important inbred mouse strains, such as C57BL/6, C3H/He, DBA/2, and 129/Sv. Scriptaid treatment enhances newly synthesized mRNA levels in cloned embryos. 250 nM Scriptaid treated for up to 48 h, does not inhibit the development of ICSI-fertilized embryos. Scriptaid inhibits T. gondii tachyzoite proliferation with IC50 of 39 nM. Scriptaid (0.225 μM) completely protects the HS68 monolayers from T. gondii tachyzoite.
in vivo: Scriptaid elicits a dose-dependent decrease in lesion size (a maximal decrease of 45%) at 1.5 to 5.5 mg/kg and a concomitant attenuation in motor and cognitive deficits when delivered 30 minutes postinjury in a model of mode rate TBI. Comparable protection is achieved even when treatment is delayed to 12 h postinjury. The protection of motor and cognitive functions is long lasting, as similar improvements are detected 35 days postinjury. Scriptaid induces an increase in surviving neurons (42%), as well as the number/length of their processes within the CA3 region of the hippocampus and the pericontusional cortex. Scriptaid treatment prevents the decrease in phospho-AKT (p-AKT) and phosphorylated phosphatase and tensin homolog deleted on chromosome 10 ( p-PTEN) induced by TBI in cortical and CA3 hippocampal neurons. Scriptaid treatment (3.5 mg/kg) clearly inhibits tumor growth in a human breast cancer xenograft MDA-MB-231 model, reducing tumor volume by 75%.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice. Gaur V, Connor T, Venardos K, Henstridge DC, Martin SD, Swinton C, Morrison S, Aston-Mourney K, Gehrig SM, van Ewijk R, Lynch GS, Febbraio MA, Steinberg GR, Hargreaves M, Walder KR, McGee SL.Diabetes Obes Metab. 2017 Feb 2. doi: 10.1111/dom.12896. [Epub ahead of print] PMID: 28155245
2:Scriptaid Upregulates Expression of Development-Related Genes, Inhibits Apoptosis, and Improves the Development of Somatic Cell Nuclear Transfer Mini-Pig Embryos. Zhang L, Huang Y, Wu Y, Si J, Huang Y, Jiang Q, Lan G, Guo Y, Jiang H.Cell Reprogram. 2017 Feb;19(1):19-26. doi: 10.1089/cell.2016.0033. Epub 2017 Jan 5. PMID: 28055234
3:Effects of the histone deacetylase inhibitor 'Scriptaid' on the developmental competence of mouse embryos generated through round spermatid injection. Kong P, Yin M, Chen D, Li S, Li Y, Xing F, Jiang M, Fang Z, Lyu Q, Chen X.Hum Reprod. 2017 Jan;32(1):76-87. Epub 2016 Nov 17. PMID: 27864358
4:Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Pradhan S, Mahajan D, Kaur P, Pandey N, Sharma C, Srivastava T.Oncotarget. 2016 Nov 1;7(44):71841-71855. doi: 10.18632/oncotarget.12378. PMID: 27708247 Free PMC Article
5:Scriptaid Treatment Decreases DNA Methyltransferase 1 Expression by Induction of MicroRNA-152 Expression in Porcine Somatic Cell Nuclear Transfer Embryos. Liang S, Zhao MH, Choi JW, Kim NH, Cui XS.PLoS One. 2015 Aug 11;10(8):e0134567. doi: 10.1371/journal.pone.0134567. eCollection 2015. PMID: 26261994 Free PMC Article
6:Effects of Scriptaid on the Histone Acetylation, DNA Methylation and Development of Buffalo Somatic Cell Nuclear Transfer Embryos. Sun H, Lu F, Zhu P, Liu X, Tian M, Luo C, Ruan Q, Ruan Z, Liu Q, Jiang J, Wei Y, Shi D.Cell Reprogram. 2015 Oct;17(5):404-14. doi: 10.1089/cell.2014.0084. Epub 2015 Jun 2. PMID: 26035741
7:The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells. Berghauser Pont LM, Kleijn A, Kloezeman JJ, van den Bossche W, Kaufmann JK, de Vrij J, Leenstra S, Dirven CM, Lamfers ML.PLoS One. 2015 May 18;10(5):e0127058. doi: 10.1371/journal.pone.0127058. eCollection 2015. PMID: 25993039 Free PMC Article
8:Effects of scriptaid on the histone acetylation of buffalo oocytes and their ability to support the development of somatic cell nuclear transfer embryos. Sun H, Lu F, Liu X, Tian M, Ruan Z, Zhu P, Ruan Q, Jiang J, Shi D.Theriogenology. 2015 Apr 15;83(7):1219-25. doi: 10.1016/j.theriogenology.2015.01.003. Epub 2015 Jan 8. PMID: 25640327
9:Combination of S-adenosylhomocysteine and scriptaid, a non-toxic epigenetic modifying reagent, modulates the reprogramming of bovine somatic-cell nuclear transfer embryos. Zhang H, Wang Y, Sang Y, Zhang Y, Hua S.Mol Reprod Dev. 2014 Jan;81(1):87-97. doi: 10.1002/mrd.22287. Epub 2013 Dec 17. PMID: 24347442
10:The histone deacetylase inhibitor Scriptaid improves in vitro developmental competence of ovine somatic cell nuclear transferred embryos. Wen BQ, Li J, Li JJ, Tian SJ, Sun SC, Qi X, Cai WT, Chang QL.Theriogenology. 2014 Jan 15;81(2):332-9. doi: 10.1016/j.theriogenology.2013.09.032. Epub 2013 Oct 6. PMID: 24182741


price inquiry for CAS:287383-59-9, Product:Scriptaid