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Piperazine CAS: 110-85-0

Category: Inhibitors
Product Name: Piperazine
Cat No: I000437
CAS No: 110-85-0
Molecular Formula: C4H10N2
Molecular Weight: 86.14
InChI: None
InChIKey: None
Solubility: 10 mM in DMSO
Target: None
CAS 110-85-0,Piperazine
  • Description

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen in the ring, firstly used as an anthelmintic in the 1950s.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1:1-(4-[18F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine: A Novel Suitable Radioligand with Low Lipophilicity for Imaging σ1 Receptors in the Brain. He Y, Xie F, Ye J, Deuther-Conrad W, Cui B, Wang L, Lu J, Steinbach J, Brust P, Huang Y, Lu J, Jia H.J Med Chem. 2017 May 8. doi: 10.1021/acs.jmedchem.6b01723. [Epub ahead of print] PMID: 28409931
2:Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents. Gurdal EE, Turgutalp B, Gulcan HO, Erçetin T, Sahin MF, Durmaz I, Atalay RC, Nguyen QD, Sippl W, Yarim M.Anticancer Agents Med Chem. 2017 Apr 12. doi: 10.2174/1871520617666170412153604. [Epub ahead of print] PMID: 28403780
3:Synthesis of Some Unique Carbamate Derivatives bearing 2-Furoyl-1-piperazine as a Valuable Therapeutic Agents. Abbasi A Muhammad, Hussain G, Rehman AU, Siddiqui Z Sabahat, Shah AA Syed, Lodhi A Muhammad, Khan A Farman, Ashraf M, Ain QU, Ahmad I, Malik R, Shahid M, Mushtaq Z.Acta Chim Slov. 2017 mac;64(1):159-169. PMID: 28380217
4:Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors. Sun J, Ren SZ, Lu XY, Li JJ, Shen FQ, Xu C, Zhu HL.Bioorg Med Chem. 2017 May 1;25(9):2593-2600. doi: 10.1016/j.bmc.2017.03.038. Epub 2017 Mar 19. PMID: 28363444
5:Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Singh A, Rani A, Gut J, Rosenthal PJ, Kumar V.Chem Biol Drug Des. 2017 Mar 23. doi: 10.1111/cbdd.12982. [Epub ahead of print] PMID: 28332319
6:Piperazine-functionalized C60 and diiodine or iodine monochloride as components in forming supramolecular assemblies. Aghabali A, Jun S, Olmstead MM, Balch AL.Dalton Trans. 2017 Mar 14;46(11):3710-3715. doi: 10.1039/c7dt00026j. PMID: 28256674
7:Crystal structure of a chloride-bridged copper(II) dimer: piperazine-1,4-dium bis-(di-μ-chlorido-bis[(4-carboxypyridine-2-carboxyl-ato-κ2N,O2)chlorido-cuprate(II)]. Inah BE, Ayi AA, Adhikary A.Acta Crystallogr E Crystallogr Commun. 2017 Jan 27;73(Pt 2):246-249. doi: 10.1107/S2056989017001013. eCollection 2017 Feb 1. PMID: 28217352 Free PMC Article
8:Retraction: Mechanism of action of novel piperazine containing a toxicant against human liver cancer cells. PeerJ Editorial Office..PeerJ. 2016 Jun 26;4. pii: e1588/retraction. doi: 10.7717/peerj.1588/retraction. eCollection 2016. PMID: 28133563 Free PMC Article
9:B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor. Post-Munson DJ, Pieschl RL, Molski TF, Graef JD, Hendricson AW, Knox RJ, McDonald IM, Olson RE, Macor JE, Weed MR, Bristow LJ, Kiss L, Ahlijanian MK, Herrington J.Eur J Pharmacol. 2017 Mar 15;799:16-25. doi: 10.1016/j.ejphar.2017.01.037. Epub 2017 Jan 26. PMID: 28132910
10:Group 12 metal complexes of (2-piperazine-1-yl-ethyl)-pyridin-2-yl-methylene-amine: rare participation of terminal piperazine N in coordination leads to structural diversity. Purkait S, Aullón G, Zangrando E, Chakraborty P.Dalton Trans. 2017 Feb 14;46(7):2184-2195. doi: 10.1039/c6dt04578b. PMID: 28127596

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