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Amrubicin hydrochloride CAS: 110311-30-3

Category: Inhibitors
Product Name: Amrubicin hydrochloride
Cat No: I000424
CAS No: 110311-30-3
Molecular Formula: C25H26ClNO9
Molecular Weight: 519.93
Solubility: 10 mM in DMSO
Target: Topoisomerase II
CAS 110311-30-3,Amrubicin hydrochloride
  • Description

Amrubicin hydrochloride (SM-5887 hydrochloride) is a topoisomerase II inhibitor used in the treatment of lung cancer.
Target: Topoisomerase II
SM-5887 is a novel anthracycline derivative. The distribution of SM-5887 in the bladder mucosa and muscular layer was almost equal, but the concentration of its active metabolite, 13-OH derivative, was 5 to 10 times higher in the bladder mucosa than in the bladder muscular layer. The distributions of SM-5887 in the organs other than the bladder, that is, the cortex and medulla of kidney, heart, lung, liver, and spleen, were very low, and those of a 13-OH active metabolite were even lower. In addition, SM-5887 barely affected the normal bladder mucosa. In dogs instilled with 80 mg of SM-5887, no histological change was observed in the bladder mucosa and submucosal layer even after 6-hour retention at the highest concentration of 8,000 micrograms/ml [1]. SM-5887 is possibly most potent for the treatment of NSCLC, and that these drugs have less cardiotoxicity compared to the mother compound, doxorubicin [2].

  • References

[1]. Ohmori, H., T. Tsushima, and K. Kobashi, [Experimental studies on intravesical instillation of SM-5887, a novel anthracycline derivative for treatment of bladder carcinoma]. Gan To Kagaku Ryoho, 1996. 23(5): p. 601-6.
[2]. Ueoka, H., T. Ohnoshi, and I. Kimura, [New anthracycline analogues in the treatment of lung cancer]. Gan To Kagaku Ryoho, 1992. 19(13): p. 2146-9.

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