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Indoximod CAS: 110117-83-4

Category: Inhibitors
Product Name: Indoximod
Cat No: I000417
CAS No: 110117-83-4
Synonyms: (E)-3'-methyl-3''-styryl-3,2':5',2'':5'',3'''-quaterpyridine
Molecular Formula: C12H14N2O2
Molecular Weight: 218.3
SMILES: CN1C2=CC=CC=C2C(C[C@H](C(O)=O)N)=C1
InChI: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
InChIKey: ZADWXFSZEAPBJS-SNVBAGLBSA-N
Solubility: 10 mM in DMSO, H2O: < 6.4 mg/mL
Target: IDO
Storage: Store at -20°C
CAS 110117-83-4,Indoximod
  • Description

Indoximod is an IDO pathway inhibitor, and reverses IDO-mediated immune suppression.
Target: IDO
in vitro: Indoximod significantly reverses the suppression of T cells created by IDO-expressing dendritic cells, using both human monocyte-derived dendritic cells and murine dendritic cells isolated directly from tumor-draining lymph nodes. Indoximod activates a Trp sufficiency signal that stimulates mTOR, and relieves IDO-induced Trp deprivation as well as an autophagic response.
in vivo: In mouse models of transplantable melanoma and transplantable and autochthonous breast cancer, Indoximod enhances antitumor immunity in the setting of combined chemo-immunotherapy regimens.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:Indoximod Combo Triggers Responses in Melanoma. [No authors listed]Cancer Discov. 2017 Apr 5. doi: 10.1158/2159-8290.CD-NB2017-056. [Epub ahead of print] PMID: 28381404
2:A phase I study of indoximod in patients with advanced malignancies. Soliman HH, Minton SE, Han HS, Ismail-Khan R, Neuger A, Khambati F, Noyes D, Lush R, Chiappori AA, Roberts JD, Link C, Vahanian NN, Mautino M, Streicher H, Sullivan DM, Antonia SJ.Oncotarget. 2016 Apr 19;7(16):22928-38. doi: 10.18632/oncotarget.8216. PMID: 27008709 Free PMC Article
3:A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors. Soliman HH, Jackson E, Neuger T, Dees EC, Harvey RD, Han H, Ismail-Khan R, Minton S, Vahanian NN, Link C, Sullivan DM, Antonia S.Oncotarget. 2014 Sep 30;5(18):8136-46. PMID: 25327557 Free PMC Article


price inquiry for CAS:110117-83-4, Product:Indoximod