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AEG40826 CAS: 1107664-44-7

Category: Inhibitors
Product Name: AEG40826
Cat No: I000416
CAS No: 1107664-44-7
Synonyms: HGS1029; HGS-1029; HGS 1029; AEG40826; AEG-40826; AEG 40826; AEG408262 HCl.;NONE
Molecular Formula:
Molecular Weight:
Solubility: Soluble in DMSO, not in water
Target: IAP Inhibitor
Storage: 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
CAS 1107664-44-7,AEG40826
  • Description

AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


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