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β-Nicotinamide mononucleotide CAS: 1094-61-7

Category: Inhibitors
Product Name: β-Nicotinamide mononucleotide
Cat No: I000399
CAS No: 1094-61-7
Synonyms: β-NMN, β-Nicotinamide ribose monophosphate, NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate
Molecular Formula: C11H15N2O8P
Molecular Weight: 334.2
MDL No: MFCD00038748
SMILES: O[C@H]1[C@@H](O)[C@H]([N+]2=CC(C(N)=O)=CC=C2)O[C@@H]1COP(O)([O-])=O
Solubility: H2O: ≥ 35 mg/mL
Storage: -20°C
CAS 1094-61-7,β-Nicotinamide mononucleotide
  • Description

β-Nicotinamide mononucleotide(cas 1094-61-7) is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

  • Spec

Purity: 95%  HPLC

  • References

1: Ummarino S, Mozzon M, Zamporlini F, Amici A, Mazzola F, Orsomando G, Ruggieri S, Raffaelli N. Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay. Food Chem. 2017 Apr 15;221:161-168. doi: 10.1016/j.foodchem.2016.10.032. Epub 2016 Oct 11. PubMed PMID: 27979136.
2: Martínez-Moñino AB, Zapata-Pérez R, García-Saura AG, Gil-Ortiz F, Pérez-Gilabert M, Sánchez-Ferrer á. Characterization and mutational analysis of a nicotinamide mononucleotide deamidase from Agrobacterium tumefaciens showing high thermal stability and catalytic efficiency. PLoS One. 2017 Apr 7;12(4):e0174759. doi: 10.1371/journal.pone.0174759. eCollection 2017. PubMed PMID: 28388636; PubMed Central PMCID: PMC5384747.
3: Wei CC, Kong YY, Li GQ, Guan YF, Wang P, Miao CY. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. Sci Rep. 2017 Apr 6;7(1):717. doi: 10.1038/s41598-017-00851-z. PubMed PMID: 28386082; PubMed Central PMCID: PMC5429727.
4: Yao Z, Yang W, Gao Z, Jia P. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci Lett. 2017 Apr 24;647:133-140. doi: 10.1016/j.neulet.2017.03.027. Epub 2017 Mar 19. PubMed PMID: 28330719.
5: Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. PubMed PMID: 28068222.

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