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PLpro inhibitor CAS: 1093070-14-4

Category: Inhibitors
Product Name: PLpro inhibitor
Cat No: I000390
CAS No: 1093070-14-4
Synonyms: (Z)-5-((Z)-(1-hydroxyethylidene)amino)-2-methyl-N-((R)-1-(naphthalen-1-yl)ethyl)benzimidic acid
Molecular Formula: C22H22N2O2
Molecular Weight: 346.42
SMILES: CC1=C(/C(O)=N/[C@](C2=CC=CC3=CC=CC=C32)([H])C)C=C(/N=C(O)/C)C=C1
Solubility: DMSO: ≥ 42 mg/mL
Target: SARS-CoV
IC50: 2.6 uM [1]
Storage: Store at -20°C
CAS 1093070-14-4,PLpro inhibitor
  • Description

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.
IC50 Value: 2.6 uM [1]
Target: PLpro; SARS-CoV
in vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].
in vivo:

  • References

[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.
[2]. http://www.google.com/patents/WO2010022355A1cl=en

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