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PP121 CAS: 1092788-83-4

Category: Inhibitors
Product Name: PP121
Cat No: I000387
CAS No: 1092788-83-4
Synonyms: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Formula: C17H17N7
Molecular Weight: 319.4
SMILES: NC1=C(C(C2=CN=C(NC=C3)C3=C2)=NN4C5CCCC5)C4=NC=N1
InChI: None
InChIKey: NVRXTLZYXZNATH-UHFFFAOYSA-N
Solubility: DMSO ≥61mg/mL Water <1.2mg/mL Ethanol ≥1.8mg/mL
Target: PI3K
Storage: powder
CAS 1092788-83-4,PP121
  • Description

PP121 is dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). PP121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP121 blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121. Peng Y, Zhou Y, Cheng L, Hu D, Zhou X, Wang Z, Xie C, Zhou F.Biochem Biophys Res Commun. 2015 Sep 11;465(1):137-44. doi: 10.1016/j.bbrc.2015.07.147. Epub 2015 Jul 30. PMID: 26235881
2:PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, inhibits anaplastic thyroid carcinoma cell proliferation and migration. Che HY, Guo HY, Si XW, You QY, Lou WY.Tumour Biol. 2014 Sep;35(9):8659-64. doi: 10.1007/s13277-014-2118-3. Epub 2014 May 28. PMID: 24867098
3:PP121. Expression of PlGF, sFlt, MTF-1, HO-1 and HIF-1 alpha mRNAs in preeclampsia placenta and effect of preeclampsia sera on their expression of choriocarcinoma cells. Maebayashi A, Yamamoto T, Azuma H, Kato E, Kuno S, Murase T, Chishima F.Pregnancy Hypertens. 2012 Jul;2(3):304-5. doi: 10.1016/j.preghy.2012.04.232. Epub 2012 Jun 13. PMID: 26105443


price inquiry for CAS:1092788-83-4, Product:PP121