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G-418 disulfate CAS: 108321-42-2

Category: Inhibitors
Product Name: G-418 disulfate
Cat No: I000364
CAS No: 108321-42-2
Synonyms: 2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
Molecular Formula: C20H40N4O10 • 2H2SO4
Molecular Weight: 692.7
SMILES: O=S(O)(O)=O.O=S(O)(O)=O.N[C@H]1[C@@H]([C@H]([C@@H]([C@H](C1)N)O[C@@]2([C@@H]([C@H]([C@@H]([C@]([H])(O2)[C@@H](C)O)O)O)N)[H])O)O[C@@]3([C@@H]([C@H]([C@@](O)(CO3)C)NC)O)[H]
Solubility: H2O: > 30 mg/mL
Target: Antibiotic
Storage: None
CAS 108321-42-2,G-418 disulfate
  • Description

G418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1; blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
IC50 value:
G-418 is an aminoglycoside related to Gentamicin, and is commonly used as a selective agent for eukaryotic cells. As an analog of neomycin sulfate, it interferes with the function of 80S ribosomes and protein synthesis in eukaryotic cells.

  • Spec

Source:Biosynthetic: produced by Micromonospora rhodorangea.
Absorbance:1mg/ml (water): 280nm <0.015 570nm <0.01 100mg/ml (water): 570nm <0.01 1.74g/25 ml (water): 280nm <0.7

  • References

[1]. G-418, From Wikipedia

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