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N-Acetyl-Calicheamicin CAS: 108212-76-6

Category: Inhibitors
Product Name: N-Acetyl-Calicheamicin
Cat No: I000357
CAS No: 108212-76-6
Molecular Formula: C57H76IN3O22S4
Molecular Weight: 1410.39
Solubility: 10 mM in DMSO
Target: Antibacterial
CAS 108212-76-6,N-Acetyl-Calicheamicin
  • Description

N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic.
Target: Antibacterial
N-Acetyl-Calicheamicin is a a derivative of Calicheamicin. Calicheamicin is a naturally occurring hydrophobic enediyne antibiotic that was isolated from the actinomycete Micromonospora echinospora calichensis. Calicheamicin can interfere with biological processes not simply by cleaving free DNA but also by displacing a DNA-binding protein through competition or modulation of DNA structure.

  • References

[1]. Stasi R, et al. Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer Treat Rev. 2008 Feb;34(1):49-60.

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