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CP-466722 CAS: 1080622-86-1

Category: Inhibitors
Product Name: CP-466722
Cat No: I000354
CAS No: 1080622-86-1
Synonyms: 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine
Molecular Formula: C17H15N7O2
Molecular Weight: 349.35
InChI: None
InChIKey: None
Solubility: DMSO: 0.28 mg/mL, H2O: <1 mg/mL
Target: ATM/ATR
Storage: powder
CAS 1080622-86-1,CP-466722
  • Description

CP-466722 is rapidly reversible potential ATM kinase inhibitor.
IC50 Value:
Target: ATM
CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP-466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP-466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP-466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

[1]. Rainey MD et al (2008) Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74.
[2]. Kuroda S, Urata Y, Fujiwara T.Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization.Acta Med Okayama. 2012;66(2):83-92.

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