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AAI-101 CAS: 1001404-83-6

Category: Inhibitors
Product Name: AAI-101
Cat No: I000352
CAS No: 1001404-83-6
Synonyms: AAI-101; AAI-101; AAI-101;(2S,3S,5R)-3-methyl-3-((3-methyl-1H-1,2,3-triazol-3-ium-1-yl)methyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
Molecular Formula: C11H14N4O5S
Molecular Weight: 314.316
SMILES: C[N+]1=NN(C[C@@](S([C@]2([H])C3)(=O)=O)(C)[C@H](C([O-])=O)N2C3=O)C=C1
InChI: InChI=1S/C11H14N4O5S/c1-11(6-14-4-3-13(2)12-14)9(10(17)18)15-7(16)5-8(15)21(11,19)20/h3-4,8-9H,5-6H2,1-2H3/t8-,9+,11+/m1/s1
Solubility: Soluble in DMSO
Target: Beta Lactamase Inhibitor
Storage: 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
CAS 1001404-83-6,AAI-101
  • Description

AAI-101 is a beta lactamase inhibitor potentially for the treatment of multi-drug resistant gram-negative bacterial infections.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1: Crandon JL, Nicolau DP. In vivo activities of simulated human doses of cefepime and cefepime-AAI101 against multidrug-resistant Gram-negative Enterobacteriaceae. Antimicrob Agents Chemother. 2015 May;59(5):2688-94. doi: 10.1128/AAC.00033-15. PubMed PMID: 25712356; PubMed Central PMCID: PMC4394792.
2: Crandon JL, Nicolau DP. In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae. Pathogens. 2015 Aug 18;4(3):620-5. doi: 10.3390/pathogens4030620. PubMed PMID: 26295262; PubMed Central PMCID: PMC4584277.
3: Bush K. A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents. 2015 Nov;46(5):483-93. doi: 10.1016/j.ijantimicag.2015.08.011. Review. PubMed PMID: 26498989.

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