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Cevimeline CAS: 107233-08-9

Category: Inhibitors
Product Name: Cevimeline
Cat No: I000333
CAS No: 107233-08-9
Synonyms: (±)-cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]
Molecular Formula: C10H17NOS
Molecular Weight: 199.32
Solubility: in DMSO > 10 mM
Target: Muscarinic Receptor
Storage: Store at -20°C
CAS 107233-08-9,Cevimeline
  • Description

Cevimeline (cas 107233-08-9) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.

  • Spec

Purity: >98%

  • References

1: Brimhall J, Jhaveri MA, Yepes JF. Efficacy of cevimeline vs. pilocarpine in the secretion of saliva: a pilot study. Spec Care Dentist. 2013 May-Jun;33(3):123-7. doi: 10.1111/scd.12010. Epub 2013 Jan 7. PubMed PMID: 23600983.
2: Ono K, Inagaki T, Iida T, Wakasugi-Sato N, Hosokawa R, Inenaga K. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats. Arch Oral Biol. 2012 Apr;57(4):421-8. doi: 10.1016/j.archoralbio.2011.09.013. Epub 2011 Nov 17. PubMed PMID: 22099058.
3: Ueda H, Mitoh Y, Ichikawa H, Kobashi M, Yamashiro T, Matsuo R. Cevimeline enhances the excitability of rat superior salivatory neurons. J Med Invest. 2009;56 Suppl:267-9. PubMed PMID: 20224198.
4: Sato N, Ono K, Haga K, Yokota M, Inenaga K. Effects of cevimeline on salivation and thirst in conscious rats. Arch Oral Biol. 2007 Jan;52(1):26-9. Epub 2006 Oct 17. PubMed PMID: 17049480.

price inquiry for CAS:107233-08-9, Product:Cevimeline