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Cevimeline hydrochloride CAS: 107220-28-0

Category: Inhibitors
Product Name: Cevimeline hydrochloride
Cat No: I000332
CAS No: 107220-28-0
Synonyms: AF 102B;SNI 2011;SNK 508
Molecular Formula: C10H17NOS • HCl
Molecular Weight: 235.8
Solubility: Soluble to 75 mM in water and to 50 mM in DMSO
Target: M3 receptor
Storage: -20°C
CAS 107220-28-0,Cevimeline hydrochloride
  • Description

Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.
IC50 value:
Target: M3 receptor

  • Spec

Appearance:A crystalline solid

  • References

[1]. Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.
[2]. Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17.
[3]. Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14.
[4]. Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9.
[5]. Tajiri S, et al. Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.Int J Pharm. 2010 Jan 4;383(1-2):99-105. Epub 2009 Sep 10.

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