CAS No. : 1065559-56-9

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For research use only. Not Intended for Therapeutic Use!
Cat No:I000323
Molecular Formula:C18H14O8
Molecular Weight:358.3
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Appearance:Solid powder
Purity: > 98%
Cat No:I000323
Cas No:1065559-56-9

SMND-309 is a novel derivative of salvianolic acid B, and has shown protective effects against rat cortical neuron damage in vitro and in vivo.
IC50 value:
SMND-309 mitigated the effects of ischemia and reperfusion injury on brain by decreasing the infract volume, improving neurological function, increasing the survival of neurons and promoting angiogenesis by increasing the levels of erythropoietin (EPO), erythropoietin receptor (EPOR), phosphorylated JAK2 (P-JAK2), phosphorylated STAT3 (P-STAT3), VEGF and VEGF receptor 2 (Flk-1) in the brain.

1:SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway. Wang Y, Zhang J, Han M, Liu B, Gao Y, Ma P, Zhang S, Zheng Q, Song X.Pharm Biol. 2016 Oct;54(10):1982-90. doi: 10.3109/13880209.2015.1137951. Epub 2016 Feb 24. PMID: 26911316
2:SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. Zhu H, Zou L, Tian J, Du G, Gao Y.Eur J Pharmacol. 2013 Aug 15;714(1-3):23-31. doi: 10.1016/j.ejphar.2013.05.043. Epub 2013 Jun 11. PMID: 23764464
3:SMND-309 promotes angiogenesis in human umbilical vein endothelial cells through activating erythropoietin receptor/STAT3/VEGF pathways. Du G, Zhu H, Yu P, Wang H, He J, Ye L, Fu F, Zhang J, Tian J.Eur J Pharmacol. 2013 Jan 30;700(1-3):173-80. doi: 10.1016/j.ejphar.2012.12.013. Epub 2012 Dec 28. PMID: 23276662
4:Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis. Hou J, Tian J, Jiang W, Gao Y, Fu F.Eur J Pharmacol. 2011 Jan 10;650(1):390-5. doi: 10.1016/j.ejphar.2010.10.019. Epub 2010 Oct 20. PMID: 20969856
5:Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats. Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J.Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):317-23. doi: 10.1111/j.1742-7843.2009.00490.x. Epub 2009 Nov 11. PMID: 19912162 Free Article
6:Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats. Tian J, Fu F, Li G, Gao Y, Zhang Y, Meng Q, Li C, Liu F.Phytomedicine. 2009 Aug;16(8):726-33. doi: 10.1016/j.phymed.2009.01.007. Epub 2009 May 28. PMID: 19481432
7:SMND-309, a novel derivate of salvianolic acid B, ameliorates cerebral infarction in rats: characterization and role. Tian J, Fu F, Li G, Wang Y, Gao Y, Liu Z, Zhang S.Brain Res. 2009 Mar 31;1263:114-21. doi: 10.1016/j.brainres.2009.01.034. Epub 2009 Jan 31. PMID: 19368834
8:SMND-309, a novel derivate of salvianolic acid B, attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons. Tian J, Li G, Zhang S, Gao Y, Jiang W, Fu F, Liu Z.Basic Clin Pharmacol Toxicol. 2009 Feb;104(2):176-84. doi: 10.1111/j.1742-7843.2008.00349.x. Epub 2008 Dec 16. PMID: 19143749 Free Article
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