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Dafadine-A CAS: 1065506-69-5

Category: Inhibitors
Product Name: Dafadine-A
Cat No: I000322
CAS No: 1065506-69-5
Synonyms: None
Molecular Formula: C23H25N3O3
Molecular Weight: 391.46
Solubility: 10 mM in DMSO
Target: CYP3A/CYP450
Storage: Store at -20°C
CAS 1065506-69-5,Dafadine-A
  • Description

Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).
IC50 value:
Target: DAF-9(CYP27A1) inhibitor
The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.

  • References

[1]. Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3.

price inquiry for CAS:1065506-69-5, Product:Dafadine-A