For research use only. Not Intended for Therapeutic Use!
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Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.
Doxycycline is a tetracycline antibiotic which is commonly used to treat a variety of infections. Doxycycline treatment resulted in a 96% loss of Wolbachia, as determined by real time PCR from microfilariae. The mechanism of doxycycline is similar to that in other filarial species, i.e., a predominant blockade of embryogenesis, leading to a decline of microfilariae according to their half-life . Doxycycline treatment inhibits the activity of tissue MMP and attenuates the decrease in the collagen content in aortas of mice haploinsufficient for collagen III, as well as prevents the development of stress-induced vessel pathology. The results suggest that doxycycline merits clinical testing as a treatment for vEDS . One person from the doxycycline group died from HIV infection. Five (doxycycline) and 11 (placebo) individuals were absent at the time of ultrasound analysis. Doxycycline treatment almost completely eliminated microfilaraemia at 8-14 months/' follow-up (for all timepoints p<0.001). Ultrasonography detected adult worms in only six (22%) of 27 individuals treated with doxycycline compared with 24 (88%) of 27 with placebo at 14 months after the start of treatment (p<0.0001) .
. Hoerauf, A., et al., Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol, 2003. 192(4): p. 211-6.
. Briest, W., et al., Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther, 2011. 337(3): p. 621-7.
. Taylor, M.J., et al., Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet, 2005. 365(9477): p. 2116-21.