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Mizolastine dihydrochloride CAS: 1056596-82-7

Category: Inhibitors
Product Name: Mizolastine dihydrochloride
Cat No: I000292
CAS No: 1056596-82-7
Synonyms: 2-((1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-4-yl)(methyl)amino)pyrimidin-4-ol dihydrochloride
Molecular Formula: C24H27Cl2FN6O
Molecular Weight: 505.42
SMILES: CN(C1=NC=CC(O)=N1)C2CCN(C3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CC2.Cl.Cl
Solubility: 10 mM in DMSO
Target: Histamine Receptor
Storage: Store at -20°C
CAS 1056596-82-7,Mizolastine dihydrochloride
  • Description

Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
Target: Histamine H1-receptor
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. It does not prevent the actual release of histamine from mast cells, just prevents it binding to receptors. Side effects can include dry mouth and throat.
Mizolastine has demonstrated antiallergic effects in animals and healthy volunteers and anti-inflammatory activity in animal models. Double-blind trials have shown mizolastine to be significantly more effective than placebo and as effective as other second generation antihistamine agents, such as loratadine or cetirizine, in the management of patients with perennial or seasonal allergic rhinitis and in patients with chronic idiopathic urticaria. Available data also suggest that prophylactic administration of mizolastine is significantly more effective than placebo and as effective as prophylactic terfenadine in delaying the onset of symptoms of seasonal allergic rhinitis.

  • References


[1]. Prakash A, et al. Mizolastine: a review of its use in allergic rhinitis and chronic idiopathic urticaria. BioDrugs. 1998 Jul;10(1):41-63.


price inquiry for CAS:1056596-82-7, Product:Mizolastine dihydrochloride