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A778317 CAS: 808756-64-1

Category: Inhibitors
Product Name: A778317
Cat No: I000290
CAS No: 808756-64-1
Synonyms: A778317;1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-isoquinolin-5-ylurea
Molecular Formula: C23H25N3O
Molecular Weight: 359.473
InChI: InChI=1S/C23H25N3O/c1-23(2,3)17-8-9-18-15(13-17)7-10-21(18)26-22(27)25-20-6-4-5-16-14-24-12-11-19(16)20/h4-6,8-9,11-14,21H,7,10H2,1-3H3,(H2,25,26,27)/t21-/m1/s1
Solubility: Soluble in DMSO
Target: TRPV1
CAS 808756-64-1,A778317
  • Description

A778317(cas 808756-64-1) is a novel, stereoselective, high-affinity antagonist that potently blocks transient receptor potential vanilloid-1 (TRPV1) receptor-mediated changes in intracellular calcium concentrations (pIC50 = 8.31 ± 0.13).

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1: Bianchi BR, El Kouhen R, Chen J, Puttfarcken PS. Binding of [(3)H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord. Eur J Pharmacol. 2010 May 10;633(1-3):15-23. doi: 10.1016/j.ejphar.2010.02.004. Epub 2010 Feb 11. PubMed PMID: 20153316.
2: Bianchi BR, El Kouhen R, Neelands TR, Lee CH, Gomtsyan A, Raja SN, Vaidyanathan SN, Surber B, McDonald HA, Surowy CS, Faltynek CR, Moreland RB, Jarvis MF, Puttfarcken PS. [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J Pharmacol Exp Ther. 2007 Oct;323(1):285-93. Epub 2007 Jul 27. PubMed PMID: 17660385.

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