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A-582941 CAS: 848591-89-9

Category: Inhibitors
Product Name: A-582941
Cat No: I000286
CAS No: 848591-89-9
Synonyms: A-582941;3-{5-methyl-octahydropyrrolo[3,4-c]pyrrol-2-yl}-6-phenylpyridazine
Molecular Formula: C17H20N4
Molecular Weight: 280.375
InChI: InChI=1S/C17H20N4/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13/h2-8,14-15H,9-12H2,1H3
Solubility: Soluble in DMSO
Target: alpha7 nicotinic acetylcholine receptor agonist
CAS 848591-89-9,A-582941
  • Description

A-582941(cas 848591-89-9)is a new alpha7 nicotinic acetylcholine receptor agonist.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1: Toyohara J, Ishiwata K, Sakata M, Wu J, Nishiyama S, Tsukada H, Hashimoto K. In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. PLoS One. 2010 Feb 1;5(2):e8961. doi: 10.1371/journal.pone.0008961. PubMed PMID: 20126539; PubMed Central PMCID: PMC2813863.
2: Thomsen MS, Mikkelsen JD, Timmermann DB, Peters D, Hay-Schmidt A, Martens H, Hansen HH. The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat. Neuroscience. 2008 Jun 23;154(2):741-53. doi: 10.1016/j.neuroscience.2008.03.083. Epub 2008 Apr 16. PubMed PMID: 18495359.
3: Tietje KR, Anderson DJ, Bitner RS, Blomme EA, Brackemeyer PJ, Briggs CA, Browman KE, Bury D, Curzon P, Drescher KU, Frost JM, Fryer RM, Fox GB, Gronlien JH, Håkerud M, Gubbins EJ, Halm S, Harris R, Helfrich RJ, Kohlhaas KL, Law D, Malysz J, Marsh KC, Martin RL, Meyer MD, Molesky AL, Nikkel AL, Otte S, Pan L, Puttfarcken PS, Radek RJ, Robb HM, Spies E, Thorin-Hagene K, Waring JF, Ween H, Xu H, Gopalakrishnan M, Bunnelle WH. Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. CNS Neurosci Ther. 2008 Spring;14(1):65-82. doi: 10.1111/j.1527-3458.2008.00037.x. Review. PubMed PMID: 18482100.
4: Buccafusco JJ, Terry AV Jr, Decker MW, Gopalakrishnan M. Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys. Biochem Pharmacol. 2007 Oct 15;74(8):1202-11. Epub 2007 Jul 14. PubMed PMID: 17706609.

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