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Tyrphostin A9 CAS: 10537-47-0

Category: Inhibitors
Product Name: Tyrphostin A9
Cat No: I000285
CAS No: 10537-47-0
Synonyms: 2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
Molecular Formula: C18H22N2O
Molecular Weight: 282.4
SMILES: CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C#N)\C#N)=C1
InChI: InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
InChIKey: MZOPWQKISXCCTP-UHFFFAOYSA-N
Solubility: 10 mM in DMSO
Target: VEGFR
Storage: powder
CAS 10537-47-0,Tyrphostin A9
  • Description

Tyrphostin A9(AG 17), a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst.
IC50 value:
Target: Multi tyrosine kinase
Tyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings suggest that signaling via PDGF receptor tyrosine kinases is not necessary for the shift of the smooth muscle cells from a contractile to a synthetic phenotype. On the other hand these enzymes apparently carry out important functions in the control of intracellular membrane traffic and cell division.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Park SJ, Park YJ, Shin JH, Kim ES, Hwang JJ, Jin DH, Kim JC, Cho DH.Biochem Biophys Res Commun. 2011 May 13;408(3):465-70. doi: 10.1016/j.bbrc.2011.04.053. Epub 2011 Apr 19. PMID: 21527248
2:Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts. Lakkakorpi PT, Nakamura I, Young M, Lipfert L, Rodan GA, Duong LT.J Cell Sci. 2001 Jan;114(Pt 1):149-160. PMID: 11112699 Free Article
3:Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. Thyberg J.Eur J Cell Biol. 1998 May;76(1):33-42. PMID: 9650781
4:Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. Marhaba R, Mary F, Pelassy C, Stanescu AT, Aussel C, Breittmayer JP.J Immunol. 1996 Aug 15;157(4):1468-73. PMID: 8759727


price inquiry for CAS:10537-47-0, Product:Tyrphostin A9