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A-438079 HCl CAS: 899431-18-6 (HCl)

Category: Inhibitors
Product Name: A-438079 HCl
Cat No: I000283
CAS No: 899431-18-6 (HCl)
Related CAS: 899507-36-9 (free base)
Synonyms: A-438079 ; A 438079; A438079; A-438079 HCl.;3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride
Molecular Formula: C13H10Cl3N5
Molecular Weight: 342.608
SMILES: ClC1=CC=CC(C2=NN=NN2CC3=CN=CC=C3)=C1Cl.Cl
InChI: InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H
InChIKey: MBTJFFMIPPMRGR-UHFFFAOYSA-N
Solubility: Soluble in DMSO, not in water
Target: P2X7 receptor antagonist
CAS 899431-18-6 (HCl),A-438079 HCl
  • Description

A-438079 HCl (cas 899431-18-6) is a P2X7 receptor antagonist. 

A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1: Jimenez-Pacheco A, Mesuret G, Sanz-Rodriguez A, Tanaka K, Mooney C, Conroy R, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC, Engel T. Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079. Epilepsia. 2013 Sep;54(9):1551-61. doi: 10.1111/epi.12257. Epub 2013 Jun 28. PubMed PMID: 23808395.
2: Marcellino D, Suárez-Boomgaard D, Sánchez-Reina MD, Aguirre JA, Yoshitake T, Yoshitake S, Hagman B, Kehr J, Agnati LF, Fuxe K, Rivera A. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7. doi: 10.1007/s00702-010-0400-0. Epub 2010 Apr 13. PubMed PMID: 20387084.


price inquiry for CAS:899431-18-6 (HCl), Product:A-438079 HCl