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Tacrolimus CAS: 104987-11-3

Category: Inhibitors
Product Name: Tacrolimus
Cat No: I000276
CAS No: 104987-11-3
Synonyms: None
Molecular Formula: C44H69NO12
Molecular Weight: 804.0
SMILES: O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O
InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/
Solubility: DMSO: ≥ 28 mg/mL
Target: Antibiotic
IC50: 0.47 nM (Inhibition of lymphocyte proliferation)
Storage: powder
CAS 104987-11-3,Tacrolimus
  • Description

Tacrolimus(cas 104987-11-3) is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects.

Clinical trial: PK Tacrolimus in Transplants. Phase 4

  • Spec

Appearance: White powder
Melting Point: 871.7°C
Loss on Drying: ≤3.0%

  • References

1: Jusko WJ, Kobayashi M. Therapeutic monitoring of tacrolimus (FK 506). Ther Drug Monit. 1993 Aug;15(4):349. PubMed PMID: 7694395.
2: Piekoszewski W, Chow FS, Jusko WJ. Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. Drug Metab Dispos. 1993 Jul-Aug;21(4):690-8. PubMed PMID: 7690698.
3: Piekoszewski W, Jusko WJ. Plasma protein binding of tacrolimus in humans. J Pharm Sci. 1993 Mar;82(3):340-1. PubMed PMID: 7680714.
4: Jegasothy BV, Ackerman CD, Todo S, Fung JJ, Abu-Elmagd K, Starzl TE. Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. Arch Dermatol. 1992 Jun;128(6):781-5. PubMed PMID: 1376102; PubMed Central PMCID: PMC3208344.
5: Min DI, Brown T, Hwang GC. Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. Am J Hosp Pharm. 1992 Dec;49(12):2964-6. PubMed PMID: 1282779.

price inquiry for CAS:104987-11-3, Product:Tacrolimus