Naspm trihydrochloride

CAS No. : 1049731-36-3

Naspm trihydrochloride,1049731-36-3
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000273
Synonyms:N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
Molecular Formula:C22H34N4O • 3HCl
Molecular Weight:479.3
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Appearance:A crystalline solid
Cat No:I000273
Cas No:1049731-36-3
Product-Name:Naspm trihydrochloride

Naspm 3Hcl(1-Naphthylacetyl spermine) is a potent and selective Ca2+ permeable AMPA receptor(Ca-perm AMPAR) blocker.
IC50 value:
Target: CP-AMPAR blocker
Naspm is a selective blocker of Ca(2+)-permeable GluA2-lacking AMPA receptors, reduced MNNG-induced CA1 pyramidal cell death [1]. intra-ACC injections of the CP-AMPAR channel antagonist, 1-naphthylacetyl spermine (NASPM) immediately following trace fear conditioning blocked 24 h fear memory retrieval [2]. TNF-α+PDC caused considerable MN degeneration was blocked by the Ca-perm AMPAr selective blocker, 1-naphthyl acetylspermine (NASPM) [3]. Blockage of CP-AMPARs with Naspm (100μM) results in most cases in a significant reduction of the PPD magnitude, also reversing to paired-pulse facilitation in some cases [4].

[1]. Gerace E, et al. PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca(2+)-permeable AMPA receptors. Neurobiol Dis. 2014 Oct;70:43-52.
[2]. Descalzi G, et al. Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning. Mol Brain. 2012 Feb 3;5:6.
[3]. Yin HZ, et al. TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec;238(2):93-102.
[4]. Shypshyna MS, et al. Presynaptic Ca(2+)-permeable AMPA-receptors modulate paired-pulse depression in nociceptive sensory synapses. Neurosci Lett. 2015 Jan 12;585:1-5.

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