Home> Products> Inhibitors> MDA 19-CAS 1048973-47-2
price inquiry for CAS:1048973-47-2, Product:MDA 19

MDA 19 CAS: 1048973-47-2

Category: Inhibitors
Product Name: MDA 19
Cat No: I000271
CAS No: 1048973-47-2
Synonyms: (2Z)-2-(1-hexyl-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide, benzoic acid
Molecular Formula: C21H23N3O2
Molecular Weight: 349.4
SMILES: O=C(/C1=N\NC(C2=CC=CC=C2)=O)N(CCCCCC)C3=C1C=CC=C3
InChI: None
InChIKey: ZGQHMZCITJHYOW-QOCHGBHMSA-N
Solubility: 10 mM in DMSO
Target: CB2 receptor
IC50: 43.3 nM(Ki)
Storage: -20°C
CAS 1048973-47-2,MDA 19
  • Description

MDA 19 is a selective human CB2 receptor agonist with Ki of 43.3 nM.
IC50 Value: 43.3 nM(Ki)
Target: CB2 receptor
in vitro: MDA19 displayed 4-fold-higher affinity at the human CB(2) than at the human CB1 receptor (K(i) = 43.3 +/- 10.3 vs 162.4 +/- 7.6 nM) and nearly 70-fold-higher affinity at the rat CB2 than at the rat CB1 receptor (K(i) = 16.3 +/- 2.1 vs 1130 +/- 574 nM). In guanosine triphosphate (GTP)gamma[(35)S] functional assays, MDA19 behaved as an agonist at the human CB1 and CB2 receptors and at the rat CB1 receptor but as an inverse agonist at the rat CB2 receptor. In 3',5'-cyclic adenosine monophosphate (cAMP) assays, MDA19 behaved as an agonist at the rat CB1 receptor and exhibited no functional activity at the rat CB(2) receptor. In extracellular signal-regulated kinases 1 and 2 activation assays, in vivo: MDA19 behaved as an agonist at the rat CB2 receptor. MDA19 attenuated tactile allodynia produced by spinal nerve ligation or paclitaxel in a dose-related manner in rats and CB2(+/+) mice but not in CB2(-/-) mice, indicating that CB2 receptors mediated the effects of MDA19. MDA19 did not affect rat locomotor activity.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells. Zhu C, Dong Y, Liu H, Ren H, Cui Z.Biomed Pharmacother. 2017 Apr;88:124-133. doi: 10.1016/j.biopha.2016.11.089. Epub 2017 Jan 16. PMID: 28103505
2:Panax ginseng Fraction F3 Extracted by Supercritical Carbon Dioxide Protects against Oxidative Stress in ARPE-19 Cells. Yang CC, Chen CY, Wu CC, Koo M, Yu ZR, Wang BJ.Int J Mol Sci. 2016 Oct 13;17(10). pii: E1717. PMID: 27754362 Free PMC Article
3:Apigenin Attenuates Oxidative Injury in ARPE-19 Cells thorough Activation of Nrf2 Pathway. Xu X, Li M, Chen W, Yu H, Yang Y, Hang L.Oxid Med Cell Longev. 2016;2016:4378461. Epub 2016 Aug 31. PMID: 27656262 Free PMC Article
4:Assessment of Cytokeratin-19 Gene Expression in Peripheral Blood of Breast Cancer Patients and Breast Cancer Cell Lines. Keyvani S, Karimi N, Orafa Z, Bouzari S, Oloomi M.Biomark Cancer. 2016 Apr 28;8:57-63. doi: 10.4137/BIC.S38229. eCollection 2016. PMID: 27147896 Free PMC Article
5:Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities. Schneider G, Kiss A, Mernyák E, Benke Z, Wölfling J, Frank É, Bózsity N, Gyovai A, Minorics R, Zupkó I.Steroids. 2016 Jan;105:113-20. doi: 10.1016/j.steroids.2015.12.003. Epub 2015 Dec 11. PMID: 26686898
6:MOLECULAR EFFECTS OF AMINE DERIVATIVES OF PHENOTHIAZINE ON CANCER CELLS C-32 AND SNB-19 IN VITRO. Latocha M, Zięba A, Polaniak R, Kuśmierz D, Nowosad A, Jurzak M, Romuk E, Kokocińska M, Sliupkas-Dyrda E.Acta Pol Pharm. 2015 Sep-Oct;72(5):909-15. PMID: 26665397 Free Article
7:Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway. Xu XR, Yu HT, Yang Y, Hang L, Yang XW, Ding SH.Eur J Pharmacol. 2016 Jan 5;770:1-8. doi: 10.1016/j.ejphar.2015.11.050. Epub 2015 Nov 28. PMID: 26643168
8:PRDX6 Protects ARPE-19 Cells from Oxidative Damage via PI3K/AKT Signaling. Zha X, Wu G, Zhao X, Zhou L, Zhang H, Li J, Ma L, Zhang Y.Cell Physiol Biochem. 2015;36(6):2217-28. doi: 10.1159/000430186. Epub 2015 Jul 24. PMID: 26279427 Free Article
9:Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and (19)F MRI. Zhou H, Hallac RR, Lopez R, Denney R, MacDonough MT, Li L, Liu L, Graves EE, Trawick ML, Pinney KG, Mason RP.Am J Nucl Med Mol Imaging. 2015 Jan 15;5(2):143-53. eCollection 2015. PMID: 25973335 Free PMC Article
10:Interaction and cytotoxic effects of hydrophobized chitosan nanoparticles on MDA-MB-231, HeLa and Arpe-19 cell lines. Almada M, Burboa MG, Robles E, Gutiérrez LE, Valdés MA, Juárez J.Curr Top Med Chem. 2014;14(6):692-701. PMID: 24444157


price inquiry for CAS:1048973-47-2, Product:MDA 19