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MI 2 MALT1 inhibitor CAS: 1047953-91-2

Category: Inhibitors
Product Name: MI 2 MALT1 inhibitor
Cat No: I000268
CAS No: 1047953-91-2
Molecular Formula: C19H17Cl3N4O3
Molecular Weight: 455.72
SMILES: O=C(NC1=CC=C(N2N=C(OCCOC)N=C2C3=CC=C(Cl)C(Cl)=C3)C=C1)CCl
InChI: None
InChIKey: None
Solubility: DMSO: ≥ 46 mg/mL
Target: MALT1
IC50: 5.84 uM
CAS 1047953-91-2,MI 2 MALT1 inhibitor
  • Description

MI 2(MALT1 inhibitor) is a small molecule and irreversible inhibitor of MALT1 with IC50 of 5.84 uM(suppression of proliferation in ABCDLBCL).
IC50 value: 5.84 uM
Target: MALT1
MI-2 selectively killed ABC-DLBCL cell lines with CD79A/B, CARMA1, and/or MYD88 mutations but not those occurring in proteins downstream of MALT1, including those with A20 homozygous deletion or TAK1 mutation. Both MI-2 and Z-VRPR-FMK reduced nuclear c-REL to a similar extent, without affecting whole-cell levels of this protein. In both cell lines, exposure to MI-2 caused a clear reduction of nuclear c-REL whereas it did not affect p65 levels.

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo
By Fontan, Lorena; Yang, Chenghua; Kabaleeswaran, Venkataraman; Volpon, Laurent; Osborne, Michael J.; Beltran, Elena; Garcia, Monica; Cerchietti, Leandro; Shaknovich, Rita; Yang, Shao Ning; et al
From Cancer Cell (2012), 22(6), 812-824.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:Short Communication: Preferential Killing of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor. Li H, He H, Gong L, Fu M, Wang TT.AIDS Res Hum Retroviruses. 2016 Feb;32(2):174-7. doi: 10.1089/AID.2015.0343. PMID: 26728103 Free PMC Article
2:Antibiotic therapy-induced remission of bladder mucosa-associated lymphoid tissue (MALT) lymphoma carrying t(11;18)(q21;q21) apoptosis inhibitor 2-MALT1. Lucioni M, Nicola M, Riboni R, Croci GA, Rattotti S, Gotti M, Arcaini L, Paulli M, Cristina S, Valentini S, Martinengo C.J Clin Oncol. 2013 Jul 1;31(19):e304-6. doi: 10.1200/JCO.2012.46.4800. Epub 2013 May 20. No abstract available. PMID: 23690413


price inquiry for CAS:1047953-91-2, Product:MI 2 MALT1 inhibitor