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Afuresertib hydrochloride CAS: 1047645-82-8

Category: Inhibitors
Product Name: Afuresertib hydrochloride
Cat No: I000266
CAS No: 1047645-82-8
Synonyms: GSK2110183B
Molecular Formula: C18H17Cl2FN4OS • HCl
Molecular Weight: 463.8
SMILES: FC1=CC=CC(C[C@@H](CN)NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)S2)=O)=C1.Cl
InChIKey: YFQJOPFTGMHYNV-YDALLXLXSA-N
Solubility: DMSO: ≥ 52 mg/mL
Storage: -20°C
CAS 1047645-82-8,Afuresertib hydrochloride
  • Description

Afuresertib Hcl (GSK2110183 Hcl) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).

  • Spec


Assay:≥98%
Appearance:A crystalline solid

  • References


[1]. Spencer A, et al. Novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma: Phase 1 study results. Blood. 2014 Jul 29. pii: blood-2014-03-559963.


price inquiry for CAS:1047645-82-8, Product:Afuresertib hydrochloride