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Afuresertib CAS: 1047644-62-1

Category: Inhibitors
Product Name: Afuresertib
Cat No: I000265
CAS No: 1047644-62-1
Synonyms: N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
Molecular Formula: C18H17Cl2FN4OS
Molecular Weight: 427.32
Solubility: DMSO: ≥ 40 mg/mL
Target: PKB
Storage: Store at -20°C
CAS 1047644-62-1,Afuresertib
  • Description

Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).

  • References

[1]. Spencer A, et al. Novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma: Phase 1 study results. Blood. 2014 Jul 29. pii: blood-2014-03-559963.

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