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GSK2141795 hydrochloride CAS: 1047635-80-2

Category: Inhibitors
Product Name: GSK2141795 hydrochloride
Cat No: I000264
CAS No: 1047635-80-2
Synonyms: N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide hydrochloride
Molecular Formula: C18H17Cl3F2N4O2
Molecular Weight: 465.71
SMILES: CN1C(C(C=C(O2)C(N[C@@](CN)([H])CC3=CC(F)=C(F)C=C3)=O)=C2Cl)=C(Cl)C=N1.Cl
Solubility: 10 mM in DMSO
Target: Akt
IC50: 180/328/38 nM (Akt1/2/3)
Storage: Store at -20°C
CAS 1047635-80-2,GSK2141795 hydrochloride
  • Description

GSK2141795 Hcl is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).
IC50 value: 180/328/38 nM (Akt1/2/3)
Target: pan-Akt inhibitor
KD values of 16 nM for Akt1, 49 nM for Akt2, and 5 nM for Akt3 (for GSK2141795), which are in line with literature data from biochemical assays that report potencies of 2 nM for Akt1, 2-13 nM for Akt2, and 3-9 nM Akt3 for GSK690693.

  • References

[1]. Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.

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