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GSK2141795 CAS: 1047634-65-0

Category: Inhibitors
Product Name: GSK2141795
Cat No: I000263
CAS No: 1047634-65-0
Synonyms: N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
Molecular Formula: C18H16Cl2F2N4O2
Molecular Weight: 429.2
SMILES: FC1=CC=C(C[C@@H](CN)NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)C=C1F
InChIKey: AXTAPYRUEKNRBA-JTQLQIEISA-N
Solubility: DMSO: ≥ 36 mg/mL
Target: Akt
IC50: 180/328/38 nM (Akt1/2/3)
Storage: Store at -20°C
CAS 1047634-65-0,GSK2141795
  • Description

GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).
IC50 value: 180/328/38 nM (Akt1/2/3)
Target: pan-Akt inhibitor
KD values of 16 nM for Akt1, 49 nM for Akt2, and 5 nM for Akt3 (for GSK2141795), which are in line with literature data from biochemical assays that report potencies of 2 nM for Akt1, 2-13 nM for Akt2, and 3-9 nM Akt3 for GSK690693.

  • Spec


Assay:≥98%
Appearance:A crystalline solid

  • References


[1]. Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.


price inquiry for CAS:1047634-65-0, Product:GSK2141795