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6-O-α-Maltosyl-β-cyclodextrin CAS: 104723-60-6

Category: Inhibitors
Product Name: 6-O-α-Maltosyl-β-cyclodextrin
Cat No: I000261
CAS No: 104723-60-6
Molecular Formula: C54H90O45
Molecular Weight: 1459.27
Solubility: H2O: ≥ 60.5 mg/mL
CAS 104723-60-6,6-O-α-Maltosyl-β-cyclodextrin
  • Description

6-O-α-maltosyl-β cyclodextrin (Mal-βCD) is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol and is much less cytotoxic to human erythrocytes and Caco-2 cells; a cyclodextrin derivative.
IC50 value:
Target:
Mal-βCD removes cellular cholesterol forming inclusion complexes, while Mal-βCD-induced lack of cellular cholesterol was replenished by the addition of CLM without cytotoxicity. Cholesterol reduction by Mal-βCD abolishes the mRNA and protein expression of ABCA1 and ABCG1, but not of P-gp.

  • References


[1]. Okada Y, et al. Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. Carbohydr Res. 2012 Aug 1;357:68-74.


price inquiry for CAS:104723-60-6, Product:6-O-α-Maltosyl-β-cyclodextrin