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A-4250 CAS: 501692-44-0

Category: Inhibitors
Product Name: A-4250
Cat No: I000257
CAS No: 501692-44-0
Synonyms: A-4250; A4250; A 4250;(S)-2-((R)-2-(2-((3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,2,5]thiadiazepin-8-yl)oxy)acetamido)-2-(4-hydroxyphenyl)acetamido)butanoic acid
Molecular Formula: C37H48N4O8S2
Molecular Weight: 740.93
SMILES: CC[C@H](NC([C@H](NC(COC1=C(SC)C=C(C2=C1)N(C3=CC=CC=C3)CC(CCCC)(CCCC)NS2(=O)=O)=O)C4=CC=C(O)C=C4)=O)C(O)=O
InChI: InChI=1S/C37H48N4O8S2/c1-5-8-19-37(20-9-6-2)24-41(26-13-11-10-12-14-26)29-21-31(50-4)30(22-32(29)51(47,48)40-37)49-23-33(43)39-34(25-15-17-27(42)18-16-25)35(44)38-28(7-3)36(45)46/h10-18,21-22,28,34,40,42H,5-9,19-20,23-24H2,1-4H3,(H,38,44)(H,39,43)(H,45,46
InChIKey: XULSCZPZVQIMFM-IPZQJPLYSA-N
Solubility: Soluble in DMSO
Target: ileal bile acid transporter (IBAT) inhibitor
CAS 501692-44-0,A-4250
  • Description

A-4250(cas 501692-44-0) is an ileal bile acid transporter (IBAT) inhibitor potentially for the treatment of primary biliary cirrhosis

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1: Graffner H, Gillberg PG, Rikner L, Marschall HU. The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation. Aliment Pharmacol Ther. 2016 Jan;43(2):303-10. doi: 10.1111/apt.13457. PubMed PMID: 26527417.
2: Baghdasaryan A, Fuchs CD, Österreicher CH, Lemberger UJ, Halilbasic E, Påhlman I, Graffner H, Krones E, Fickert P, Wahlström A, Ståhlman M, Paumgartner G, Marschall HU, Trauner M. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis. J Hepatol. 2016 Mar;64(3):674-81. doi: 10.1016/j.jhep.2015.10.024. PubMed PMID: 26529078.


price inquiry for CAS:501692-44-0, Product:A-4250