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CAY10603 CAS: 1045792-66-2

Category: Inhibitors
Product Name: CAY10603
Cat No: I000254
CAS No: 1045792-66-2
Synonyms: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-1,1-dimethylethyl ester, carbamic acid
Molecular Formula: C22H30N4O6
Molecular Weight: 446.5
SMILES: ONC(=O)CCCCCCNC(=O)c1noc(c1)c1ccc(cc1)NC(=O)OC(C)(C)C
InChI: None
InChIKey: WWGBHDIHIVGYLZ-UHFFFAOYSA-N
Solubility: 10 mM in DMSO
Target: HDAC6 inhibitor
IC50: 2 pM [1]
Storage: -20°C
CAS 1045792-66-2,CAY10603
  • Description

CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively.
IC50 value: 2 pM [1]
Target: HDAC6 inhibitor
CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


[1]. Kozikowski AP, et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem. 2008 Aug 14;51(15):4370-3.


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