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RU-SKI 43 CAS: 1043797-53-0

Category: Inhibitors
Product Name: RU-SKI 43
Cat No: I000249
CAS No: 1043797-53-0
Synonyms: 2-((2-methylbutyl)amino)-1-(4-((m-tolyloxy)methyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone
Molecular Formula: C22H30N2O2S
Molecular Weight: 386.55
Solubility: DMSO > 50 mg/ml
Target: Hedgehog
Storage: Store at -20°C
CAS 1043797-53-0,RU-SKI 43
  • Description

RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
IC50 value:
Target: Hhat inhibitor
RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.

  • References

[1]. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.

price inquiry for CAS:1043797-53-0, Product:RU-SKI 43