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IRAK inhibitor 6 CAS: 1042672-97-8

Category: Inhibitors
Product Name: IRAK inhibitor 6
Cat No: I000246
CAS No: 1042672-97-8
Synonyms: N-(2-methoxy-4-morpholin-4-ylphenyl)-2-pyridin-3-yl-1,3-thiazole-4-carboxamide
Molecular Formula: C20H20N4O3S
Molecular Weight: 396.46
SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC(=O)C3=CSC(=N3)C4=CN=CC=C4
Solubility: 10 mM in DMSO
Target: IRAK
Storage: Store at -20°C
CAS 1042672-97-8,IRAK inhibitor 6
  • Description

IRAK inhibitor 6 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor .

  • References


[1]. Quantitative structure-activity relationship (QSAR) study of interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor activity by the genetic algorithm and multiple linear regression (GA-MLR) method By Pourbasheer, Eslam; Riahi, Siavash; Ganjali, Mo December 2010, Vol. 25, No. 6 , Pages 844-853 (doi:10.3109/14756361003757893) Abstract A linear quantitative structure-activity relationship (QSAR) model is presented for the modelling and prediction for the interleukin-1 receptor associated kinase 4 (IRAK-4) inhibition activity of amides and imidazo[1,2-α] pyridines. The model was produced using the multiple linear regression (MLR) technique on a database that consisted of 65 recently discovered amides and imidazo[1,2- α] pyridines. Among the different constitutional, topological, geometrical, electrostatic and quantum-chemical descriptors that were considered as inputs to the model, seven variables were selected using the genetic algorithm subset selection method (GA). The accuracy of the proposed MLR model was illustrated using the following evaluation techniques: cross-validation, validation through an external test set, and Y-randomisation. The predictive ability of the model was found to be satisfactory and could be used for designing a similar group of compounds."


price inquiry for CAS:1042672-97-8, Product:IRAK inhibitor 6