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IRAK inhibitor 1 CAS: 1042224-63-4

Category: Inhibitors
Product Name: IRAK inhibitor 1
Cat No: I000244
CAS No: 1042224-63-4
Synonyms: 6-imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyridin-2-amine
Molecular Formula: C17H19N5
Molecular Weight: 293.37
SMILES: C1CNCCC1NC2=CC=CC(=N2)C3=CN=C4N3C=CC=C4
Solubility: DMSO 12 mg/ml
Target: IRAK
Storage: Store at -20°C
CAS 1042224-63-4,IRAK inhibitor 1
  • Description

IRAK inhibitor 1 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor.

  • References


[1]. IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding By Buckley, George M.; Ceska, Thomas A.; Fraser, Joanne L.; Gowers, Lewis; Groom, Colin R.; Higueruelo, Alicia Perez; Jenkins, Kerry; Mack, Stephen R.; Morgan, Trev Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. Epub 2008 Apr 22.
[2]. Dobierzewska A, Giltiay NV, Sabapathi S, Karakashian AA, Nikolova-Karakashian MN. Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta. J Biol Chem. 2011 Sep 16;286(37):32064-73.
[3]. Joh EH, Kim DH. Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways. Br J Pharmacol. 2011 Apr;162(8):1731-42. doi: 10.1111/j.1476-5381.2010.01195.x.
[4]. Song KW, Talamas FX, Suttmann RT, Olson PS, Barnett JW, Lee SW, Thompson KD, Jin S, Hekmat-Nejad M, Cai TZ, Manning AM, Hill RJ, Wong BR. The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells. Mol Immunol. 2009 Apr;46(7):1458-66.
[5]. Lockett A, Goebl MG, Harrington MA. Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF R1. Am J Physiol Cell Physiol. 2008 Aug;295(2):C313-23.


price inquiry for CAS:1042224-63-4, Product:IRAK inhibitor 1