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A-366833 CAS: 370882-41-0

Category: Inhibitors
Product Name: A-366833
Cat No: I000241
CAS No: 370882-41-0
Synonyms: A-366833; A 366833; A366833;;3-Pyridinecarbonitrile, 5-(1R,5S)-3,6-diazabicyclo(3.2.0)hept-6-yl-
Molecular Formula: C11H12N4
Molecular Weight: 200.24
SMILES: N#CC1=CC(N2[C@]3([H])CNC[C@]3([H])C2)=CN=C1
InChI: InChI=1S/C11H12N4/c12-2-8-1-10(5-13-3-8)15-7-9-4-14-6-11(9)15/h1,3,5,9,11,14H,4,6-7H2/t9-,11-/m1/s1
InChIKey: GPXAWLDGWSBLKM-MWLCHTKSSA-N
Solubility: Soluble in DMSO, not in water
Target: None
CAS 370882-41-0,A-366833
  • Description

A-366833 is a drug developed by Abbott which acts a novel nicotinic acetylcholine receptor (nAChR) ligand that binds to the agonist-binding site ([3H]-cytisine) with Ki value of 3.1 nM and exhibits agonist selectivity at alpha4beta2 nAChR relative to the alpha3beta4 nAChR subtype. The analgesic effects of A-366833 were examined across a variety of animal models including the mouse model of writhing pain, the rat models of acute thermal, persistent chemical and neuropathic pain.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:Antinociceptive activity of α4β2* neuronal nicotinic receptor agonist A-366833 in experimental models of neuropathic and inflammatory pain. Nirogi R, Jabaris SL, Jayarajan P, Abraham R, Shanmuganathan D, Rasheed MA, Royapalley PK, Goura V.Eur J Pharmacol. 2011 Oct 1;668(1-2):155-62. doi: 10.1016/j.ejphar.2011.06.032. Epub 2011 Jul 3. Erratum in: Eur J Pharmacol. 2011 Dec 30;673(1-3):101. Jabaris, Sugin Lal [added]. PMID: 21756895
2:A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models. Ji J, Bunnelle WH, Anderson DJ, Faltynek C, Dyhring T, Ahring PK, Rueter LE, Curzon P, Buckley MJ, Marsh KC, Kempf-Grote A, Meyer MD.Biochem Pharmacol. 2007 Oct 15;74(8):1253-62. Epub 2007 Aug 12. PMID: 17854775


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