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Acetaminophen CAS: 103-90-2

Category: Inhibitors
Product Name: Acetaminophen
Cat No: I000233
CAS No: 103-90-2
Related CAS: 16958-94-4 (sodium salt)
Synonyms: 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol
Molecular Formula: C8H9NO2
Molecular Weight: 151.2
MDL No: MFCD00002328
SMILES: OC1=CC=C(NC(C)=O)C=C1
InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
InChIKey: RZVAJINKPMORJF-UHFFFAOYSA-N
Solubility: 100 mM in ethanol;100 mM in DMSO ; methanol:50 mg/ml;
Target: COX
Storage: Refrigerator
CAS 103-90-2,Acetaminophen
  • Description

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor. 

Acetaminophen acts functionally as a selective COX-2 inhibitor led us to investigate the hypothesis of whether it works via preferential COX-2 blockade. In vitro, acetaminophen elicited a 4.4-fold selectivity toward COX-2 inhibition (IC(50)=113.7 micromol/L for COX-1; IC(50)=25.8 micromol/L for COX-2). Following oral administration of the drug, maximal ex vivo inhibitions were 56% (COX-1) and 83% (COX-2). Acetaminophen plasma concentrations remained above the in vitro IC(50) for COX-2 for at least 5 h postadministration. Ex vivo IC(50) values (COX-1: 105.2 micromol/L; COX-2: 26.3 micromol/L) of acetaminophen compared favorably with its in vitro IC(50) values. In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors. However, a >95% COX-1 blockade relevant for suppression of platelet function was not achieved. 

  • Spec

Appearance: Powder
Grade: USP
Purity: 99.0%

  • References

[1]. Hinz, B., O. Cheremina, and K. Brune, Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.

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