Home> Products> Inhibitors> MBX-2982-CAS 1037792-44-1
price inquiry for CAS:1037792-44-1, Product:MBX-2982

MBX-2982 CAS: 1037792-44-1

Category: Inhibitors
Product Name: MBX-2982
Cat No: I000225
CAS No: 1037792-44-1
Synonyms: 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole
Molecular Formula: C22H24N8OS
Molecular Weight: 448.5
SMILES: CCC1=CN=C(N2CCC(C3=NC(COC4=CC=C(N5N=NN=C5)C=C4)=CS3)CC2)N=C1
InChI: InChI=1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,1H3
InChIKey: NFTMKHWBOINJGM-UHFFFAOYSA-N
Solubility: 10 mM in DMSO
Target: GPR119
Storage: Store at -20°C
CAS 1037792-44-1,MBX-2982
  • Description

MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.
IC50 value:
Target: GPR119
MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


[1]. BRIAN ROBERTS, FRANCINE M. GREGOIRE, DAVID B. KARPF et al. MBX-2982, a Novel Oral GPR119 Agonist for the Treatment of Type 2 Diabetes: Results of Single & Multiple Dose Studies.
[2]. Gater D. 32nd National Medicinal Chemistry Symposium--medicinal chemistry developments for neurodegeneration, diabetes and cancer. Drugs. 2010 Aug;13(8):514-6.
[3]. Jones RM, Leonard JN, Buzard DJ, Lehmann J. GPR119 agonists for the treatment of type 2 diabetes. Expert Opin Ther Pat. 2009 Oct;19(10):1339-59.


price inquiry for CAS:1037792-44-1, Product:MBX-2982