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Taltirelin CAS: 103300-74-9

Category: Inhibitors
Product Name: Taltirelin
Cat No: I000198
CAS No: 103300-74-9
Molecular Formula: C17H23N7O5
Molecular Weight: 405.41
Solubility: DMSO:≥ 32 mg/mL
Target: Others
CAS 103300-74-9,Taltirelin
  • Description

Taltirelin(TA0910), a novel orally active TRH analogue, binds to rat brain TRH receptors in vivo.
Target: Others
Taltirelin(TA0910), a novel orally active TRH analogue, binds to rat brain TRH receptors in vivo. Effects of taltirelin hydrate (CAS 103300-74-9, TA-0910), a novel thyrotropin-releasing hormone (TRH) analog, on the cerebral monoamine systems, especially the release and turnover of dopamine (DA) in rat brain were compared with those of TRH by intraperitoneal administration. Taltirelin hydrate (1-10 mg/kg) increased the extracellular levels of DA and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the nucleus accumbens and corpus striatum for 3 h in a microdialysis study. taltirelin hydrate possesses not only an enhancing effect on DA release, but also a stimulating effect on the monoamine system [1]. Taltirelin selectively bound to TRH receptors and increased the spontaneous motor activity by a single administration, suggesting that the motor effect of taltirelin is mediated by TRH receptors [2].

  • References


[1]. Fukuchi, I., et al., Effects of taltirelin hydrate (TA-0910), a novel thyrotropin-releasing hormone analog, on in vivo dopamine release and turnover in rat brain. Arzneimittelforschung, 1998. 48(4): p. 353-9.
[2]. Asai, H., et al., Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacol Biochem Behav, 2005. 82(4): p. 646-51.


price inquiry for CAS:103300-74-9, Product:Taltirelin