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A939572 CAS: 1032229-33-6

Category: Inhibitors
Product Name: A939572
Cat No: I000191
CAS No: 1032229-33-6
Synonyms: 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide
Molecular Formula: C20H22ClN3O3
Molecular Weight: 387.9
SMILES: ClC1=CC=CC=C1OC2CCN(C(NC3=CC(C(NC)=O)=CC=C3)=O)CC2
InChI: InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
InChIKey: DPYTYQFYDLYWHZ-UHFFFAOYSA-N
Solubility: DMSO: ≥ 56 mg/mL
Target: SCD
IC50: <4 nM (mSCD1); 37 nM (hSCD1) [1]
Storage: Store at -20°C
CAS 1032229-33-6,A939572
  • Description

A939572 (SCD1 inhibitor) is a potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1 respectively.
IC50 value: <4 nM (mSCD1); 37 nM (hSCD1) [1]
Target: SCD1
in vitro: A939572 is a small molecule that specifically inhibits SCD1 enzymatic activity. A939572 showed a significant dose-dependent decrease in proliferation in Caki1, A498, Caki2, and ACHN at day 5 (IC50s of 65, 50, 65, and 6 nmol/L, respectively). In congruity with previous experimentation examining SCD1 lentiviral knockdown models, A939572 induced apoptosis confirmed by PARP cleavage via Western blot analysis in all 4 cell lines. InA939572 (SCDi) treated Caki1 and A498 cells, all 5 endoplasmic reticulum stress related genes were expressed at significantly increased levels compared to DMSO t BSA control, and this elevated expression could be blocked with the addition of OA-BSA [2].
in vivo: Athymic nude (nu/nu) mice bearing A498 ccRCC xenografts were treated with A939572 and Tem individually or in
combination over the course of 4 weeks, and tumor volume (mm3) was recorded [2].

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


[1]. Xin Z, et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302.
[2]. von Roemeling CA, et al. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013 May 1;19(9):2368-80.


price inquiry for CAS:1032229-33-6, Product:A939572